Molecular Aspects of Wound Healing and the Rise of Venous Leg Ulceration: Omics Approaches to Enhance Knowledge and Aid Diagnostic Discovery
Identifieur interne : 000364 ( Main/Exploration ); précédent : 000363; suivant : 000365Molecular Aspects of Wound Healing and the Rise of Venous Leg Ulceration: Omics Approaches to Enhance Knowledge and Aid Diagnostic Discovery
Auteurs : Daniel A. Broszczak [Australie] ; Elizabeth R. Sydes [Australie] ; Daniel Wallace [Australie] ; Tony J. Parker [Australie]Source :
- The Clinical Biochemist Reviews [ 0159-8090 ] ; 2017.
Abstract
Chronic wounds, in particular venous leg ulcers (VLU), represent a substantial burden for economies, healthcare systems and societies worldwide. This burden is exacerbated by the recalcitrant nature of these wounds, despite best practice, evidence-based care, which substantially reduces the quality of life of patients. Furthermore, co-morbidities such as diabetes and cardiovascular disease within ageing populations further contribute to the increasing prevalence in developed countries. This review provides an overview of the literature concerning the cellular and molecular mechanisms of wound healing and aspects where this process fails, resulting in a chronic wound. VLU may arise from chronic venous disease, which presents with many clinical manifestations and can lead to a highly complex disease state. Efforts to comprehend this state using various omics based approaches have delivered some insight into the underlying biology of chronic wounds and revealed markers of differentiation at the genomic, transcriptomic, proteomic and metabolomic levels. Furthermore, this review outlines the array of analytical tools and approaches that have been utilised for capturing multivariate data at each of these molecular levels. Future developments in spatiotemporal analysis of wounds along with the integration of multiple omics datasets may provide much needed information on the key molecules that drive wound chronicity. Such biomarkers have the potential to be developed into clinically relevant diagnostic tools to aid in personalised wound management.
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PubMed: 28798504
PubMed Central: 5548371
Affiliations:
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Parker</name><affiliation wicri:level="1"><nlm:aff id="af2-cbr-38-35">Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Qld 4059, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Qld 4059</wicri:regionArea><wicri:noRegion>Qld 4059</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Clinical Biochemist Reviews</title><idno type="ISSN">0159-8090</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Chronic wounds, in particular venous leg ulcers (VLU), represent a substantial burden for economies, healthcare systems and societies worldwide. This burden is exacerbated by the recalcitrant nature of these wounds, despite best practice, evidence-based care, which substantially reduces the quality of life of patients. Furthermore, co-morbidities such as diabetes and cardiovascular disease within ageing populations further contribute to the increasing prevalence in developed countries. This review provides an overview of the literature concerning the cellular and molecular mechanisms of wound healing and aspects where this process fails, resulting in a chronic wound. VLU may arise from chronic venous disease, which presents with many clinical manifestations and can lead to a highly complex disease state. Efforts to comprehend this state using various omics based approaches have delivered some insight into the underlying biology of chronic wounds and revealed markers of differentiation at the genomic, transcriptomic, proteomic and metabolomic levels. Furthermore, this review outlines the array of analytical tools and approaches that have been utilised for capturing multivariate data at each of these molecular levels. Future developments in spatiotemporal analysis of wounds along with the integration of multiple omics datasets may provide much needed information on the key molecules that drive wound chronicity. Such biomarkers have the potential to be developed into clinically relevant diagnostic tools to aid in personalised wound management.</p></div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Broszczak, Daniel A" sort="Broszczak, Daniel A" uniqKey="Broszczak D" first="Daniel A" last="Broszczak">Daniel A. Broszczak</name></noRegion><name sortKey="Broszczak, Daniel A" sort="Broszczak, Daniel A" uniqKey="Broszczak D" first="Daniel A" last="Broszczak">Daniel A. Broszczak</name><name sortKey="Parker, Tony J" sort="Parker, Tony J" uniqKey="Parker T" first="Tony J" last="Parker">Tony J. Parker</name><name sortKey="Sydes, Elizabeth R" sort="Sydes, Elizabeth R" uniqKey="Sydes E" first="Elizabeth R" last="Sydes">Elizabeth R. Sydes</name><name sortKey="Sydes, Elizabeth R" sort="Sydes, Elizabeth R" uniqKey="Sydes E" first="Elizabeth R" last="Sydes">Elizabeth R. Sydes</name><name sortKey="Wallace, Daniel" sort="Wallace, Daniel" uniqKey="Wallace D" first="Daniel" last="Wallace">Daniel Wallace</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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